KMD Bioscience Co., Ltd. (Tianjin) is a National High-Tech Enterprise dedicated to becoming a leading provider of drug discovery and related support services. With cutting-edge technology R&D at our core, we offer high-quality, one-stop CRO (Contract Research Organization) services to scientists, research institutions, pharmaceutical and biotech companies worldwide, aiming to advance the development and innovation of medical technology.
Our foundation is built on solid quality and technology: we are a National Patent Pilot Unit, hold ISO9001:2015 Quality Management System Certification for our laboratories, and possess over 30 patents and 4 registered trademarks. Our technical team is highly skilled, with over 90% of R&D personnel holding a Master’s degree or higher, ensuring expert support for every project. Each year, we successfully deliver nearly a thousand technical service projects to global clients, covering protocol design, project consultation, and execution.
Leveraging our five core platforms—Antibody Drug Discovery, Antibody Engineering, Protein Expression & Purification, and Stable Cell Line Development—we combine deep antibody engineering expertise with advanced molecular biology technologies to formally introduce our professional Aptamer Development Service, providing clients with novel tools for research and application.
A nucleic acid aptamer (Aptamer) is a short, single-stranded DNA or RNA molecule obtained through in vitro screening technology. It can bind to target molecules (such as proteins, small molecules, cells) with high affinity and specificity, earning it the title of “chemical antibody.”
Compared to traditional antibodies, aptamers offer unique advantages: small molecular weight, ease of synthesis and modification, low immunogenicity, high stability, and minimal batch-to-batch variation. They demonstrate immense potential in disease diagnosis, targeted therapy, drug delivery, environmental monitoring, and other fields.
KMD Bioscience’s Aptamer Development Service is precisely built upon our mature Phage Display Screening Platform and extensive experience in Molecular Interaction Analysis, offering clients fully customized services from initial screening to functional validation.
Our core service process includes:
Target Analysis & Protocol Design: Our expert team collaborates with you to analyze target characteristics (protein, small molecule, cell, etc.) and tailor the screening strategy.
SELEX Screening: Utilizing state-of-the-art Systematic Evolution of Ligands by Exponential Enrichment technology to rapidly and precisely screen for aptamer sequences with specific affinity for the target from a random single-stranded nucleic acid library.
Sequence Optimization & Synthesis: Sequencing and affinity assessment of primary candidate sequences, followed by necessary truncation or chemical modification optimization to enhance stability or functionality.
Affinity & Specificity Validation: Rigorously determining the binding kinetics (KD value) and cross-reactivity of aptamers using technologies such as Surface Plasmon Resonance and Isothermal Titration Calorimetry.
Functional Application Development: Providing aptamer labeling, conjugation, and performance testing services based on the client’s intended end-use (e.g., diagnostic reagent development, biosensor construction, targeted drug delivery).
Profound Technical Expertise: We have long focused on the field of molecular recognition and binding, accumulating extensive successful experience in Phage Display Library Construction & Screening and Small Molecule Antigen-Antibody Interaction. This expertise seamlessly translates to aptamer development, ensuring a high project success rate.
Advanced Platform Support: The entire service is supported by our in-house Protein Expression & Purification Platform, Molecular Interaction Analysis Platform, and Synthetic Biology Platform. We can provide clients with high-purity target proteins and conduct multi-dimensional, rigorous validation of aptamer functionality.
“One-Stop” Service Experience: We offer a complete service chain from Target Preparation and Aptamer Screening to Sequencing, Chemical Modification, and Large-Scale Synthesis. Clients avoid the need to coordinate with multiple vendors, significantly saving time and communication costs.
High Customization & Flexible Collaboration: We deeply understand the differing needs of basic research and industrial applications. Whether for exploratory research on novel biomarkers or the development of IVD reagent raw materials or drug delivery systems, we can provide personalized project solutions.
Aptamers developed by KMD Bioscience can be widely applied in:
In Vitro Diagnostics (IVD): Serving as the core recognition element for developing highly sensitive and specific detection kits (e.g., for infectious diseases, tumor markers).
Targeted Therapy & Drug Delivery: Acting as a targeting moiety to precisely deliver drug molecules to diseased cells or tissues.
Basic Scientific Research: Serving as novel tools for protein function studies, signaling pathway analysis, and cell sorting.
Environmental & Food Safety Monitoring: Detecting small molecule contaminants such as pesticide residues, heavy metal ions, and toxins.
If you are seeking a stable, efficient, and designable targeting recognition tool to overcome the limitations of traditional antibodies, KMD Bioscience’s Aptamer Development Service is your ideal choice.
Contact us for detailed technical information or to initiate a consultation for your customized project:
Official Website: https://www.selexkmdbio.com
Service Inquiry Email:info@kmdbioscience.com
Company Address: Building A5, International Enterprise Community, Wuqing District, Tianjin
Let KMD Bioscience empower you with cutting-edge technology and professional services to unlock the limitless potential of nucleic acid aptamers and jointly push the boundaries of life science research together.
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