Nucleic acid aptamers, often termed “chemical antibodies,” exhibit high affinity and specificity for target molecules, mirroring the recognition capabilities of conventional antibodies. They present a transformative potential to supplant antibodies across diverse fields including biosensing, in vitro diagnostics, therapeutic development, and biomedical research.
Once selected, aptamers offer significant advantages: they can be chemically synthesized with exceptional batch-to-batch consistency at a fraction of the cost (typically less than 10%) of antibody production. Furthermore, they demonstrate superior stability, ease of modification, and reduced immunogenicity.
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At KMD Bioscience, our core expertise lies in the advanced screening and development of these highly structured DNA or RNA molecules. Our process is built upon the Systematic Evolution of Ligands by Exponential Enrichment (SELEX) methodology. The fundamental SELEX cycle involves:
Incubation of a vast combinatorial nucleic acid library with the target.
Partitioning to isolate target-bound sequences from unbound ones.
Amplification of the recovered sequences to generate an enriched library for the next selection round.
We leverage and continuously innovate upon this foundational technology with proprietary strategies and state-of-the-art platforms—such as Capture-SELEX, Cell-SELEX, and Next-Generation Sequencing (NGS)-accelerated approaches—to deliver high-performance aptamers with efficiency and precision for our clients’ specific applications.
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