selexkmdbio-Cellular Aptamer Screening Service

As a functional nucleic acid, aptamer has many advantages. Based on its high specificity, it can accurately find the target molecule, thus avoiding the interference caused by nonspecific binding. Through in vitro selection technology (SELEX) screening, aptamers can be synthesized rapidly and in large quantities without complex biological preparation process. Aptamers have good chemical stability, can keep their structure and function unaffected under a variety of environmental conditions, and have higher thermal stability and lower immunogenicity. The molecular weight of aptamers is relatively small, making it easier for them to penetrate cell and tissue barriers and reach the site of action quickly. The core of aptamer screening is SELEX technology, which can accurately screen nucleic acid molecules that can achieve highly specific binding with specific targets from a large number of nucleic acid libraries with diverse sequences after multiple rounds of selection and amplification cycles. DNA or RNA aptamers obtained by in vitro screening technology have a unique three-dimensional structure, which can accurately identify and tightly bind to the corresponding target molecules. Compared with traditional antibodies, aptamers exhibit a variety of advantages, such as thermal stability, chemical synthesis and modification ability, and low immunogenicity. These characteristics together determine the great application potential of aptamers in a wide range of fields, such as bioanalysis, biomedical research, sensor technology innovation, and so on.

For the samples used for aptamer screening, some requirements need to be met.