Aptamer Screening Services-Nucleic Acid Aptamer Synthesis Service

KMD Bioscience, with years of research experience in the field of aptamer development, has successfully built a comprehensive aptamer library system and accumulated profound project practical knowledge in the process. KMD Bioscience can provide customers with excellent aptamer library construction services and support subsequent research processes such as aptamer screening, nucleic acid aptamer sequence synthesis, functional validation, and aptamer development for specific molecules. KMD Bioscience has achieved sequence optimization, upgrading, and significant functional enhancement through professional nucleic acid adapter sequence synthesis services. With the help of an advanced adapter library construction platform, KMD Bioscience ensures that customers can obtain efficient and accurate nucleic acid adapter results. In addition, KMD Bioscience also has the ability to provide comprehensive aptamer library design services, covering the entire process from gene analysis synthesis, in vitro screening of aptamers, aptamer synthesis to affinity determination, striving to meet the diverse project needs of various customers.

The nucleic acid aptamer library constructed by KMD Bioscience covers a wide range of sequences and has a broad coverage. The core elements such as sequence length, GC ratio, and secondary structure in the library have been optimized to enrich the diversity of aptamers while strictly monitoring their quality. Based on years of experience in aptamer development, KMD Bioscience has conducted in-depth analysis of the screened nucleic acid aptamer sequences, extracted the common structural characteristics of these sequences, and continuously optimized sequence design by introducing mutations, adjusting sequence length, and other means to enhance the binding efficiency, stability, and biological activity of the aptamers. The adapter library capacity of KMD Bioscience is approximately 10 ^ 13 to 10 ^ 14, and can even reach the level of 10 ^ 14. With this high-capacity library and diverse screening techniques such as magnetic bead SELEX screening, cell SELEX screening, capture SELEX screening, etc., KMD Bioscience can efficiently screen for highly specific adapter sequences targeting specific targets from various samples such as proteins, small molecules, cells, and bacteria. These sequences include RNA aptamers, DNA aptamers, and oligonucleotides. Based on the obtained sequence, nucleic acid aptamer sequence synthesis is carried out, and the synthesized nucleic acid aptamer exhibits binding affinity at the nM to pM level, especially for protein targets, which can reach up to pM level. Customers only need to clarify their experimental requirements, and KMD Bioscience’s research team will tailor a solution to fully assist them in Aptamer development research exploration.