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KMD Bioscience Aptamer Screening Service: Aptamer Types

Date：2025-12-20

KMD Bioscience Aptamer Screening Service: Aptamer Types

Aptamers are oligonucleotide or peptide sequences obtained through in vitro selection techniques (such as SELEX) that exhibit high specificity and affinity for target molecules. Based on molecular composition, aptamers are primarily categorized into two main types: Nucleic Acid Aptamers and Peptide Aptamers. Both types demonstrate strong target recognition and binding capabilities.

Main Types and Characteristics

Type Composition Structure and Properties
DNA Aptamers Composed of short single-stranded DNA molecules. Can fold into specific three-dimensional structures to recognize and bind targets. Generally more stable than RNA aptamers, and easier to synthesize and modify.
RNA Aptamers Composed of short single-stranded RNA molecules. Can also fold into complex three-dimensional structures for high-specificity target binding. Often exhibit greater structural diversity, but natural RNA is susceptible to degradation and often requires chemical modifications for enhanced stability.
Peptide Aptamers Consist of short peptide sequences made of amino acids. Typically presented on a stable protein scaffold (e.g., thioredoxin). This design enhances binding affinity and stability towards the target while maintaining peptide flexibility and specificity.

Service Value

KMD Bioscience’s aptamer screening service covers all the above types. Depending on your target characteristics and research objectives (e.g., diagnostics, therapeutics, assay development), we provide end-to-end solutions—from library design and in vitro selection to affinity validation—to help you obtain high-performance aptamer molecules.