These are specialized contract research services offered by biotech companies and CROs (Contract Research Organizations) to discover, optimize, or validate peptide-based molecules for various applications. They provide the expertise, libraries, and high-throughput technologies to efficiently identify peptide hits from vast molecular collections.
This is the most common starting point for discovery.
Synthetic Peptide Libraries: Collections of thousands to millions of chemically synthesized peptides.
Positional Scanning Libraries: For epitope mapping or identifying key amino acid residues.
Truncation & Alanine Scanning: To find the minimal active sequence and critical residues.
Phage Display Libraries: The largest and most diverse format (up to 10^11 unique sequences). A library of bacteriophages, each displaying a unique peptide on its coat protein, is panned against a target (e.g., a protein, cell).
mRNA/Ribosome Display Libraries: Cell-free systems that link the peptide to its encoding mRNA, allowing for even larger libraries and easier mutagenesis.
Services are tailored to the desired peptide function:
Target-Based Screening: Against purified proteins (e.g., enzymes, receptors, GPCRs, protein-protein interaction interfaces).
Cell-Based Screening: For peptides that modulate cell signaling, internalize into cells (CPPs), or have antimicrobial (AMP) or anticancer activity.
Antigen/Antibody Screening: For epitope mapping, vaccine development, or diagnostic reagent discovery.
Anti-Microbial Peptide (AMP) Screening: Specialized assays against bacteria, fungi, or biofilms.
Material-Binding Peptide Screening: To discover peptides that bind to inorganic surfaces (e.g., gold, graphene, polymers) for nanotechnology or coatings.
Moving from initial “hits” to confirmed “leads”:
SPR (Surface Plasmon Resonance) & BLI (Bio-Layer Interferometry): For measuring binding affinity (KD) and kinetics (kon/koff).
ELISA & Competitive Binding Assays: To confirm specificity and potency.
Mass Spectrometry Analysis: For verifying sequence and post-translational modifications.
Stability & Serum Half-Life Studies: In various biological matrices.
Once a lead is identified, services to improve its properties:
Peptidomimetics & Stabilization: Incorporating D-amino acids, non-natural amino acids, cyclization (head-to-tail, disulfide), or PEGylation to enhance stability, half-life, and activity.
Affinity Maturation: Creating secondary libraries based on the lead sequence to improve binding strength.
Conjugation Services: Linking peptides to fluorophores, biotin, drugs, or carriers.
Consultation & Design: Define target, assay, and success criteria.
Library Selection/Design: Choose the appropriate library type and diversity.
High-Throughput Screening (HTS): Perform the primary screen.
Hit Identification & Sequencing: Retrieve the sequences of active peptides.
Hit Validation & Characterization: Confirm activity with purified hits.
Lead Optimization (Optional): Improve the pharmacological properties.
Data & Report Delivery: Including sequences, analytical data, and recommendations.
| Factor | Questions to Ask |
|---|---|
| Expertise & Track Record | Do they have experience in your specific field (e.g., oncology, neuroscience, diagnostics)? Can they provide case studies? |
| Technology & Library | What library platforms do they offer (phage, synthetic, etc.)? What is the diversity and quality? Do they have a proprietary platform? |
| Assay Development | Can they develop a custom assay for your unique target? Do they have robust in-house cell culture and protein production? |
| End-to-End Capability | Can they take you from discovery through optimization and even to GMP manufacturing? |
| Data & Reporting | What level of data (raw and analyzed) is provided? Is the process transparent? |
| Cost & Timeline | What is the pricing model (project-based, FTE)? What are the typical milestones and delivery times? |
| Confidentiality & IP | Who owns the intellectual property for the discovered sequences? How is data security handled? |
Large CROs: Eurofins Discovery, Charles River Laboratories, WuXi AppTec.
Specialized Peptide Companies: CPC Scientific, Mimotopes, JPT Peptide Technologies, GenScript, Peptide 2.0.
Phage Display Specialists: Dyax (now part of Takeda), Creative Biolabs, Absolute Antibody.
Peptide screening services offer a powerful, outsourced pathway to accelerate peptide drug discovery, diagnostic tool development, and basic research. By leveraging their specialized libraries, automation, and expertise, researchers can bypass the need for extensive in-house infrastructure and focus on their core biological questions.
To get started, clearly define your target, desired peptide function, and success criteria, then engage with providers for detailed project proposals.
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