aptamer screening service:Aptamer Design & Synthesis

Date：2025-12-19

Custom-Tailored Aptamers with Exceptional Affinity and Specificity for Your Target Molecules

Aptamers are powerful tools in biotechnology and therapeutic development, offering molecular recognition properties that rival traditional antibodies. In addition to their high targeting precision, custom aptamers provide distinct advantages: they are developed entirely in vitro, can be rapidly produced through chemical synthesis, exhibit excellent stability in storage, and show minimal immunogenicity in therapeutic contexts. KMDbioscience delivers a dedicated service to generate high-quality aptamers against your chosen targets, achieving reliable results even with complex or challenging molecules. Our aptamers are available with a range of fluorescent labeling options to support convenient detection and visualization in your applications.

Our custom aptamer development utilizes a proprietary SELEX technology, enabling the rapid generation of aptamers with high binding affinity for your target molecules.

Our custom aptamer services include:

Aptamer Discovery

Advanced SELEX using modified nucleotides
Traditional SELEX using natural nucleotides
Competitive and/or negative selection strategies
Maturation SELEX (second-round selection using a pre-screened focused library)

Aptamer Modification

End-Group Modification (5’ and/or 3’): Amine, Thiol, Biotin, various fluorescent dyes, PC Biotin, PC Amine, idT, Cholesterol, etc., with or without linkers (dT, dA, HEG, PEG, etc.)
Internal Modification: 2’-OMe, internal amine, internal biotin, etc.
Conjugation: Pegylation (linear, branched, lysine-branched), bead immobilization, etc.

Aptamer Characterization