Custom Aptamer Discovery Service: Our Tailored Development Process
Curious about how we identify precision-targeting aptamers? Our step-by-step workflow is designed to isolate high-affinity molecular binders for your specific target.
Our Proven Development Pathway:
1. Design & Synthesis of Custom ssDNA Library
We construct a diverse single-stranded DNA library with randomized sequences, tailored to your target’s properties for optimal screening potential.
2. Target-Specific Binding Selection
Your target molecule (protein, small molecule, or cell) is incubated with our curated DNA library under optimized conditions to capture specific binders.
3. Rigorous SELEX Enrichment Cycles
Through multiple iterative rounds of:
Stringent Washing – Removal of non-specific binders
Selective Elution – Recovery of target-bound sequences
Controlled PCR Amplification – Enrichment of high-affinity candidates
4. Next-Generation Sequencing & Bioinformatics Analysis
Deep sequencing of enriched pools followed by advanced computational analysis to identify conserved binding motifs and candidate families.
5. Comprehensive Affinity Validation
Each candidate undergoes thorough characterization including:
Kd Determination – Precise binding affinity measurement
Specificity Profiling – Cross-reactivity assessment
Functional Validation – Performance evaluation in your intended application format
Deliverables:
Fully characterized aptamer sequences with binding parameters
Specificity validation data
Optimization for your required buffer conditions
Technical support for implementation
Our Advantage: Proprietary screening methodologies, stringent counter-selection protocols, and integrated computational design ensure we deliver aptamers with superior specificity and nanomolar-range affinity for your unique applications.
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